The Journal of the American Medical Association (JAMA) conducted a randomized clinical trialregarding the use of cannabidiol (CBD) to help reduce the effect of psychosis in high risk patients. In their investigation, they compared "33 individuals at clinical high risk of psychosis, who were part of a double-blind randomized clinical trial and 19 healthy control individuals, a single oral dose of cannabidiol modulated activation in the striatum, medial temporal cortex, and midbrain. In each of these regions, the level of activation following administration of cannabidiol to patients at clinical high risk of psychosis was intermediate between the response in healthy control individuals who did not receive any drug and in patients at clinical high risk receiving placebo."
This means that the results found suggest that CBD may normalize dysfunction in brain regions implicated in psychosis.
MGRetailer reported on the study's findings as well:
“The results have started unraveling the brain mechanisms of a new drug that works in a completely different way to traditional anti-psychotics,” said the study’s lead author Dr. Sagnik Bhattacharyya from the Institute of Psychiatry, Psychology & Neuroscience at King’s College, London according to Forbes.
The study is small and researchers will want to see these results repeated in future studies before they can draw definitive conclusions on CBD’s potential to treat psychosis. Bhattacharyya also questioned the longevity of CBD’s impact and wondered if they would fade over time.
Despite the limitations, Bhattacharyya was encouraged at the possibility of CBD being used to treat psychosis.
“There is an urgent need for a safe treatment for young people at risk of psychosis,” added Dr. Bhattacharyya. “One of the main advantages of cannabidiol is that it is safe and seems to be very well tolerated, making it in some ways an ideal treatment.”
CBD products and availability have been growing in the consumer market, and giving many people with many ailments an alternative to some pharmaceuticals or damaging treatments. As more clinical studies and scientific knowledge become published and awareness grows, so will healthier treatments, derived from the cannabis plant.